Erythropoietin inhibits SGK1-dependent Th17 cell induction and Th17 cell–dependent kidney disease

Estradiol Inhibits Th17 Cell Differentiation

Th17 cell function and Th17-mediated autoimmune disease

© 2008 Pappu et al. The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 5 1049-1062 www.jem.org/cgi/doi/ 1049 10.1084/jem.20071364 After activation, CD4 + Th cells diff erentiate into distinct eff ector subsets that are characterized by their unique cytokine expression and immunoregulatory function ( 1, 2 ). A novel Th subset — termed Th IL-17 , Th17, or infl ammatory Th — has bee...

Dendritic cell MST1 inhibits Th17 differentiation

Although the differentiation of CD4+T cells is widely studied, the mechanisms of antigen-presenting cell-dependent T-cell modulation are unclear. Here, we investigate the role of dendritic cell (DC)-dependent T-cell differentiation in autoimmune and antifungal inflammation and find that mammalian sterile 20-like kinase 1 (MST1) signalling from DCs negatively regulates IL-17 producing-CD4+T help...

Biology of TH17 Lymphocytes, their Cytokines and Role in Disease

T lymphocytes that are involved in cellular mediated immunity include two types known as TCD8+ (Cytotoxic T lymphocytes) and TCD4+ (helper T lymphocytes). TCD4+ has four main subtypes, including TH1, TH2, TH17, and Treg Lymphocytes.TH17 lymphocytes play a role in defense against microbes that TH1 and TH2 lymphocytes have not the ability to respond to them. The most important cytokines, which ar...

Induction of pathogenic TH17 cells by inducible salt- sensing kinase SGK1 Citation

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Th17 response and induces pathogenic effe...